منابع مشابه
NOX Family NADPH Oxidases
Proton channels allow cells to extrude excess acid with a high efficiency and therefore are one of the important homeostatic mechanisms that maintain the intracellular pH in a range compatible with life. Proton currents are highly expressed in phagocytes where they are thought to contribute to charge and pH compensation during NADPH oxidase activation. By analogy with the cytochrome C oxidase o...
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Predictions of diabetes prevalence over the next decades warrant the aggressive discovery of new approaches to stop or reverse loss of functional beta cell mass. Beta cells are recognized to have a relatively high sensitivity to reactive oxygen species (ROS) and become dysfunctional under oxidative stress conditions. New discoveries have identified NADPH oxidases in beta cells as contributors t...
متن کاملOxidative innate immune defenses by Nox/Duox family NADPH oxidases.
The importance of reactive oxygen species (ROS) in innate immunity was first recognized in professional phagocytes undergoing a 'respiratory burst'upon activation. This robust oxygen consumption is related to a superoxide-generating enzyme, the phagocytic NADPH oxidase (Nox2-based or phox). The oxidase is essential for microbial killing, since patients lacking a functional oxidase suffer from e...
متن کاملPhysiological roles of NOX/NADPH oxidase, the superoxide-generating enzyme
NADPH oxidase is a superoxide (O(2) (•-))-generating enzyme first identified in phagocytes, essential for their bactericidal activities. Later, in non-phagocytes, production of O(2) (•-) was also demonstrated in an NADPH-dependent manner. In the last decade, several non-phagocyte-type NADPH oxidases have been identified. The catalytic subunit of these oxidases, NOX, constitutes the NOX family. ...
متن کاملBiological roles for the NOX family NADPH oxidases.
Linking the phagocyte defect in patients with chronic granulomatous disease (CGD) with the biochemical basis for oxygen consumption by stimulated neutrophils (1) represented a seminal advance in understanding the molecular basis for a key component of innate immunity. In subsequent decades, the catalytic and regulatory elements of the “respiratory burst oxidase” were elucidated, tacitly assumin...
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ژورنال
عنوان ژورنال: médecine/sciences
سال: 2015
ISSN: 0767-0974,1958-5381
DOI: 10.1051/medsci/20153101012